Workpackages
Vertebral body replacement represents one of the most challenging and invasive procedures. Even though modern surgical techniques for en bloc resection of vertebral body are consolidating, this procedure is burdened by high complication rates (45.5 %) as surgical site infections, that are critical and difficult to treat, poor bone regeneration and mechanical instability, also correlated with infections.
NANO-VERTEBRA project proposes a breakthrough approach to realize customized prosthesis to replace vertebral bodies affected by tumors or major traumatic events, specifically engineered to reduce infections and increase patients’ surgical options.
WPs Romanian team specific WPs
WP 1. Osseointegrated and antibacterial coatings for functionalized spine implants -Technical specifications; Synthesis and characterization of osseointegrated coatings on non-porous Ti substrates
Task 1.1 Technical specifications
Task 1.2 Synthesis of osseointegrated coatings on polished Ti substrates
Task 1.3 Characterization of osseointegrated coatings on polished Ti substrates
Task 1.4 Synthesis of osseointegrated and antibacterial coatings on polished Ti substrates
Task 1.5 Characterization of osseointegrated and antibacterial coatings on polished Ti substrates
Task 1.6 Optimized synthesis of osseointegrated coatings on rough Ti substrates
Task 1.7 Characterization of osseointegrated coatings on rough Ti substrates
Task 1.8 Project meeting
Task 1.8 Dissemination of the project results
WP 2. Synthesis and characterization of osseointegraed coatings on non-porous and porous Ti substrates
Task 2.1 Optimized synthesis of osseointegrated and antibacterial coatings on rough Ti substrates [video link]
Task 2.2 Characterization of osseointegrated and antibacterial coatings on rough Ti substrates
Task 2.3 Experimental configurations for the deposition of coatings on porous substrates [video link]
Task 2.4 Preliminary tests for the synthesis of osseointegrated and antibacterial coatings on porous substrates and their characterization
Task 2.5 Project meeting
Task 2.6 Dissemination of the project results
WP 3. Optimized synthesis and characterization of osseointegrated coatings on non-porous Ti substrates
Task 3.1 Optimized experimental configurations for the deposition of coatings on porous substrates
Task 3.2 Synthesis of osseointegrated coatings on porous Ti substrates
Task 3.3 Characterization of osseointegrated coatings on porous Ti substrates
Task 3.4 Synthesis of osseointegrated and antibacterial coatings on porous Ti substrates
Task 3.5 Characterization of osseointegrated and antibacterial coatings on porous Ti substrates
Task 3.6 Test lot 1 of functionalized vertebral porous implant
Task 3.7 Project meeting
Task 3.8 Dissemination
WP 4. Nanostructured and antibacterial coatings deposited on porous vertebra implant
Task 4.1 Test lot 2 of functionalized vertebral porous implant
Task 4.2 Results evaluation aiming for clinical and industrial application
Task 4.3 Final project meeting
The project proposes to implement personalized vertebral prosthesis, by combining nanostructured antibacterial and ceramic coatings to prevent infections and to promote fast and effective bone regeneration. An optimization of implant architecture by 3D modeling and additive manufacturing technologies will be also performed to maximize coverage of the prosthesis by nanocoatings, boost integration, and guarantee suitable mechanical properties and to be patient specific.